Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells
نویسندگان
چکیده
منابع مشابه
Morphological transformation, DNA damage, and chromosomal aberrations induced by a direct DNA perturbation of synchronized Syrian hamster embryo cells.
number of photochemical lesions in BrdUrd-substituted DNA than in nonsubstituted DNA. The major photoproduct is uracil, which is formed by the dissociation of bromouracil in the radical formation, and these radicals may extract an electron from the furanose backbone. This ultimately leads to a break in the DNA, particularly when it is subjected to alkaline conditions (22,35). Several studies (3...
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The cytogenetic effects of chrysotile asbestos on Syrian hamster embryo cells in vitro were investigated at doses which induced morphological and neoplastic transformation but which failed to induce measurable gene mutations in the cells at two genetic loci. Chrysotile asbestos treatment of the cells significantly induced chromosome changes in a dose-dependent manner. Up to 50% of the cells had...
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A mammalian cell culture system using normal, diploid Syrian hamster embryo fibroblasts was used as a model to study the ability of diethylstilbestrol (DES) and related compounds to induce neoplastic transformation. Like benzo(a)pyrene, a known chemical carcinogen, DES (0.01 to 10 /ig/ml) induces morphological transformation of Syrian hamster embryo fibro blasts in vitro; the transformed coloni...
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when the concentration of the exogenous metabolic system was five to ten fold that used generally. Acid-treated oils were not mutagenic to S. typhimurium in the presence of an exogenous metabolic system; solvent-refined oils were reported to be mutagenic in the presence of an exogenous metabolic system. Hydrotreated oil was reported to be mutagenic to S. typhimurium in the presence of an exogen...
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Morphological transformation of Syrian hamster embryo cells was induced by direct exposure to some inorganic salts of nickel, cadmium, chromium, beryllium, and arsenic but not salts of iron, titanium, tungstate, zinc, aluminum, and nickel sulfide amorphous. Furthermore, no transfor mation was observed in untreated controls. Lethality, mdi cated by a reduction in cloning efficiency, occurred wit...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 2000
ISSN: 0143-3334,1460-2180
DOI: 10.1093/carcin/21.4.727